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Effects on Neurological and Immune Systems in Humans
Mold and Mycotoxins: Effects on the Neurological and Immune Systems in Humans
ANDREW W. CAMPBELL, JACK D. THRASHER, MICHAEL R. Gray, AND ARISTO VOJDANI
I. Introduction ........................................................................................... 375

II Water Damage and Associated Molds.....................................................378
A.
Mycobiota................................................................................................ 378
B.
Mycotoxins Produced by Toxigenic Molds.............................................  378
C. Human Exposure....................................................................................380
III Symptoms, Upper and Lower Respiratory Tract......................................380
A.
Symptoms.................................................................................................380
B.
Upper Respiratory Fungal Infections.........................................................382
C.
Lower Respiratory Tract  ..........................................................................383
D. Proinflammatory Cytokines and Biomarkers .......................................... 385
IV. IgA, IgG, and IgE Antibodies to Molds and Mycotoxins.........................  385
 Salivary IgA Antibodies to Molds ................................................................. 385               
 A. Serum IgA, IgM, IgG, and IgE Antibodies to Molds ................................ 386
B. Cross-Reactivity of Antibodies to Molds  ..................................................387
C. Antibodies to Extracellular Polysaccharides (EPS) ................................ 390
V. Alterations in T and B Cells, Natural Killer (NK) Cells, and Other
Immune Parameters in Humans Exposed to Toxigenic Molds ................... 390
A.
Alterations in Percentage of T and B cells ............................................... 390
B.
Mitogen Activity  ........................................................................................391
C.
Autoantibodies ......................................................................................... 392
D.
Immune Complexes ................................................................................. 392
E. Concluding Remarks on Immunological Observations ........................... 393

VI Neurological Abnormalities ..................................................................... 393
A Neurocognitive Deficits and Central Nervous System Dysfunction ........  394
B. Peripheral Motor and Sensory Neuropathy ............................................ 396
A.
Neuronal Antibodies ................................................................................ 396
D. Myelination of Peripheral Nerves ...........................................................  397

VII. Conclusion ............................................................................................ 397

References ................................................................................................. 398

This paper was published in Sick Building Syndrome, Edited by David Straus, Ph.D.
 Advances in Applied Microbiology, Volume 55, 2004.
If you would like a copy of the paper email:  toxicologist1@msn.com

 Contact Information
 Cell: 575-937-1150
 Email: toxicologist1@msn.com

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