Introduction:  Streptomyces is the largest genus of the Actinobacteria with over 500 known species., belonging to the family Streptomycetaceae.  They are found predominantly in soil and decaying vegetation.  They are gram positive and have a mycelium-type growth resembling molds.  The DNA has a  high G-C content.  Most Streptomyces produce spores and the are noted for the “earthy” odor following a rain because of the production of the volatile compound, geosmin.  Streptomyces is the largest antibiotic producing genus in the microbial world.  The estimated number of secondary antimicrobial compounds  produced by this genus is estimated to be about 100,000.  These include antifungals,  antibiotics and chemotherapeutic chemicals.  Search of the National Library of Medicine via entrez pubmed gave a list of 7,683 published research papers on the subject of Streptomyces + antibiotics.  The identification and production of antimicrobial compounds produced by this genus began in the 1970s and continues to current.  The antimicrobial compounds currently or formerly in used will be briefly reviewed below. Following, this review the presence of various species of Streptomyces in damp indoor spaces will be discussed.

Antifungals From Streptomyces species.  Streptomyces  produce numerous antifungal compounds which belong toe the polyene antimycotics.  Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of antimicrobial compounds targeting molds. The polyenes bind to ergosterol in the fungal cell membrane and promote leakiness which may contribute to fungal cell death.  Their chemical structural feature is a large ring of atoms (essentially a cyclic ester ring) containing multiple conjugated carbon-carbon double bonds (hence polyene) on one side of the ring and multiple hydroxl groups bonded to the other side of the ring. Their structures often have a d-mycosamine (a type of amino-glycoside) group bonded to the molecule. The series of conjugated double bonds typically absorbs strongly in the ultraviolet-visible region of the electromagnetic spectrum, often resulting in the polyene antibiotics having a yellow color.

Examples of polyene antifungals are:  Nystatin (S. noursei), Amphotericin B (S. nodosus, and Natamycin (S. natlensis).

Antibiotics from Streptomyces species:  Streptomyces species are the source of a large number of antibiotics.  As mentioned above, over 7500 research papers have been published on this subject.  The most frequently used and medically important antibiotics are:

Eryrthromycin (S. fradiae)                  Neomycin (S. griseus)                     Streptomycin  (S. rimosus)
Tetracycline (S. Rimosus)                 Vancomycin (S. Orientals)                Daptomycin (S. Rosesporus)
Rifamycin (S. mediterranei)              Chloramphenicol (S. venezuelae)   Puromycin (S. alboniger)
Lincomycin  (S. lincolnensis)           Cefoxin (S. lactamdurans)

Chemotherapeutic Chemicals from Streptomyces species

Anthracyclines were the subject of cancer treatment since the 1970s. The  daunosamine and tetra-hydronaphthacenedione-based compounds are cell-cycle